Aging Symposia Bregenz

Creating New Networks:

July 29–August 3, 2012, Bregenz, Austria

Programs of Previous Symposia

FIRST INTERNATIONAL SYMPOSIUM, JULY 19–23, 1992.

Speakers:

Joseph Meites, Michigan State University, East Landing, USA — Special Lecture: Neuroendocrine interventions that inhibit or reverse aging processes.
Herbert Butka, University of Vienna, Austria — Neuropathology of aging and Alzheimer disease.
David Bowen, Institute of Neurology and Neurochemistry, London, United Kingdom — Neurotransmitter receptors of ocrtical pyramidal neurons: implications for disorders of the aging human brain.
Oleh Hornykiewicz, University of Vienna, Austria — Brain aging and Parkinson disease.
Paola Timiras, UC Berkeley, USA — Stress and hormones alter proteins in aging neurons.
Phyllis Wise, University of Maryland, Baltimore, USA — Cellular mechanisms and hypothalamic aging.
Marco Trabucchi, University of Rome, Italy — Pharmacology of the aging brain.
Giancarlo Pepeu, University of Florence, Italy — Central cholinergic systems and aging.
Agneta Nordberg, Uppsala University, Sweden — Sexually differentiated expression of cytochrome P450C in rate liver — a model system for studies of GH mechanisms of action.
Gad Gilad, NIMH, Washington, DC, USA — Effects of genotype on age related alterations in the stress induced response of central and peripheral neuroendocrine systems.
Engenio Müller, University of Milan, Italy — Aspects of the neuroendocrine control of growth hormone secretion.
Satya Kalra, University of Florida, USA — Aging of the neuropeptidergic signals.
Umberto Scapagnini, University of Catania, Italy — Alteration of hypothalamic function.
William Sonntag, Bowman Gray School of Medicine, USA — Significance of changes in growth hormone and insulin-like growth factors in biological aging.
Agneta Mode, Karolinska Institute, Sweden — Nicotinic reeptors and aging.
Robert Marcus, Stanford University, USA — Effects of growth hormone in the elderly.
Luciano Martini, University of Milan, Italy — Aging of the neuroendocrine brain: effects on receptor mechanisms and steroid metabolism.
Richard Steger, Southern Illinois University, USA — Premature aging in transgenic mice expressing different growth hormone genes.
Luciano Angelucci, University of Rome, Italy — Hyppocampus and behavior.

SECOND INTERNATIONAL SYMPOSIUM, JULY 24–29, 1994.

Speakers:

Paola Timiras, UC Berkeley, USA — Special Lecture: Wellness in aging: streee, homeostasis and learning.
Leonard Hayflick, UC San Francisco, USA — Cell biology of human longevity: evidence for a telomere clock.
Imre Zs. Nagy, University Medical School, Hungary — Semiconduction of proteins as an attribute of the living state.
Russel Reiter, University of Texas San Antonio, USA — The neurohormone melatonin: its relation to the pathophysiology of aging.
Gilles Pierrefiche, Hospital Boucicaut, France — Melatonin in aging and related diseases: an attempt of integrated approach from behavior to oxygen free radicals.
Takayuli Ozawa, University of Nagoya, Japan — Mitochondrial DNA mutations associated with age.
Regina Casper, Stanford University, USA — Nutrition and its relationship to aging.
Edward Masoro, University of Texas San Antonio, USA — Dietary restriction.
Patrick Rabbit, University of Manchester, United Kingdom — Memory changes in normal aging.
Donald Caspary, Southern Illinois University, USA — Neurochemical basis of auditory dysfunction with aging.
Roger Elble, Southern Illinois University, USA — The role of aging in the clinical expression of essential tremor.
Vladimir Frolkis, Institute of Gerontology, Ukraine — Role of "invertors" in the mechanisms of age-related changes of cell response to hormones.
C. Kaufmann, Ludwig-Bolzmann Institute, Austria — Integrated psychotherapy in rehabilitation, especially in older age groups.
Clarrisa Desjardins, McGill University, Canada — Estadiol-induced hypothalamic beta endorphin neuron loss: a possible model of hypothalamic aging.
Michael Meaney, McGill University, Canada — Adrenal stress and aging.
Diane Miller, Environmental Protection Agency, USA — Astrogliosis in transgenic mice expressing the bovine growth hormone gene: indication of accelerated aging.
Peter Reiderer, University of Würzburg, Germany — Aging of the dopaminergic system.
George Roth, NIA-NIH, Baltimore, USA — Changes in tissue responsiveness to hormone and neurotransmitters during aging.
Nestor Verkhratsky, Institute of Gerontology, Ukraine — Limbic structures and their influence on endocrine gland function in aged rats.
Winfred Rossmaith, University of Ulm, Germany — Gonadotropin secretion during aging in women.
James Carey, UC Davis, USA — Sex-specific life table aging rates in large medfly cohorts.
Ronald Zec, Southern Illinois University, USA — Neuropsychology of normal human aging.

THIRD INTERNATIONAL SYMPOSIUM, JULY 21–26, 1996.

Speakers:

Luciano Martini, University of Milan, Italy — Special Lecture: The brain: a vulnerable target.
Geoffrey Bennett, University of Nottingham, United Kingdom — Effect of neuropeptides on cognitive function.
Dolores M Catalá, Universidad de Valencia, Spain — Parkinson Disease.
Nicola Fabris, INRCA, Italy — Neuroendocrine-immune interaction.
Michael O Hengartner, Cold Spring Harbor Laboratory, USA — Aging and apopotosis in the nematode C. elegans.
Michel A Hofman, Netherlands Institute for Brain Research, The Netherlands — Lifespan changes in the human hypothalamus.
Thomas Kirkwood, University of Manchester, United Kingdom — Network theory of aging.
Joseph Knoll, Semmelweis University of Medicine, Hungary — Sexual performance and longevity.
S M McCann, Pennington Biomedical Research Center, USA — The nitric oxide hypothesis of brain aging.
Arshag D Mooradian, St. Louis University Health Sciences Center, USA — Age-related changes in the blood-brain barrier.
Greg Morin, Geron Corporation, USA — Telomere control of replicative lifespan.
Hans Nohl, Veterinärmedizinische Universität Wien, Austria — Imbalance of oxygen activation and energy metabolism as a consequence or mediator of aging.
Fred Nyberg, University of Uppsala, Sweden — Aging effects on growth hormone receptor binding in the brain.
Meinrad Peterlik, University of Vienna, Austria — Aging, neuroendocrine function, and osteoporosis.
Walter Pierpaoli, Biancalana-Masera Foundation for the Aged, Switzerland — Circadian melatonin and young to old pineal grafting postpone aging and maintain juvenile conditions of reproductive functions in mice and rats.
Yuan Touitou, Faculté de Médecine Pitié-Salpétrière, France — Modification of circadian and circannual rhythms with aging.
Eugenia Wang, Bloomfield Center for Research in Aging, Canada — Regulation of apoptosis resistance and ontogeny of age-dependent diseases.
Gregg Villeponteau, Geron Corporation, USA — The heterochromatin loss model of aging.
George Wick, University of Innsbruck, Austria — The aging immune system: primary and secondary alterations of immune reactivity in the elderly.
Barry Zirkin, Johns Hopkins University, USA — Leydig cell steroidogenesis in aging rats.

FOURTH INTERNATIONAL SYMPOSIUM, JULY 26–31, 1998.

Speakers:

Leonard Hayflick, Univeristy of California, San Francisco, USA — Special Lecture: How and why we age.
Andrzej Bartke, Southern Illinois University, USA — Does growth hormone prevent or accelerate aging?
Christian Behl, Max Planc Institute for Psychiatry, Germany — Effects of lgucocorticoid on exidative stree-induced hippocampal cell death: implications for the pathogenesis of Alzheimer disease.
Giovanni Biggio, University of Cagliari, Italy — Stress and neurosteroids in adult and aged rats.
Elizabeth Bock, University of Copenhagen, Denmark — Neural cell adhesion molecule [NCAM] in development and plasticity of the nervous system.
Othmar Gaber, University of Innsbruck, Austria — Man from Hauslabjoch.
Ezio Giacobini, University Hospital of Geneva University , Switzerland — Aging, Alzheimer and estrogen therapy.
Cheryl L. Grady, Rotman Research Insitute, Canada — Brain imaging and age-related changes in cognition.
Beatrix Grubeck-Loebenstein, Austrian Academy of Science, Austria — The possible role of the immune system in Alzheimer disease.
Joe Herbert, University of Cambridge, United Kingdom — Neurosteroids, brain damage and mental illness.
Karen Hsiao, University of Minnesota Medical School, USA — Transgenic mice expressing Alzheimer amyloid precursor protein.
Donald Ingram, National Institutes on Aging, USA — Application of gene therapy to treat age-related loss of dopamine D2 receptor.
S. Michal Jazwinski, Louisiana State University, USA — Genetics of longevity.
S.M. McCann, Pennington Biomedical Research Center, USA — Nitric oxide and aging.
Roberto Melcangi, University of Milan, Italy — Effects of steroid hormones on gene expression of glial markers in the central nervous system: variations induced by aging.
Tetsuro Miki, Osaka University Medical School, Japan — Transcriptional activation by the Werner syndrome gene product in yeast.
Marilyn Millter, McGill Centre for Studies on Aging, Canada — Estrogen, the ovary, and neurotransmitters: factors associated with aging.
Angelo Sagripanti, Institute of Clinical Medicine, Italy — Natural anticoagulants, aging and thromboembolism.
Stephen Sterns, University of Basel, Switzerland — The experimental evolution of aging in fruitflies.
Eva Syková, Charles University Institute of Experimental Medicine, Czech Republic — Diffusion contraints and neuron-glia interaction during aging.
F. Waldhauser, University of Vienna, Austria — Age-related changes in melatonin levels in man and their potential consequences for sleep disorders.

FIFTH INTERNATIONAL SYMPOSIUM, JULY 23–28, 2000.

Speakers:

Lars Bertram — Search for novel Alzheimer's disease genes – Results of the NIMH study.
J.M. Billard — NMDA receptor activation in aged rat hippocampus.
Greg Brewer — Neuronal plasticity and stressor toxicity during aging.
J.A. Edwardson — Multiple substrates of late-onset dementia: implications for therapy.
Ettore Ferrari — Pineal and adrenocortical function in physiological aging and in senile dementia.
Sam Gandy — Ovariectomy and 17 beta-estradiol modulate the levels of Alzheimer's amyloid beta-peptides in brain.
Siegfried Hoyer — Brain glucose and energy metabolism in sporadic Alzheimer disease: causes and consequences.
Akihisa Iguchi — The metabolism of plasma glucose and catecholamines in Alzheimer's disease.
P. Jansen-Dürr — Cell cycle regulation in aging.
Mathias Jucker — Mouse models of brain aging and Alzheimer's disease.
Adriana Maggi — Estrogens and apoptosis of neural cells.
Hari Manev — 5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus: early response to glutamate receptor activation by kainate.
Alvin M. Matsumoto — Aging and the Neuroendocrine Regulation of Reproduction and Body Weight.
Margaret A. Pericak-Vance — Genetics of Alzheimer disease.
John P. Phillips — Targeted neuronal gene expression and longevity in Drosophila.
Aurel Popa-Wagner — Brain plasticity: to what extent do aged animals retain the capacity to coordinate gene activity in response to acute challenges.
Bernard Sommer — Transgenic animals as models for degenerative diseases Mouse models of alpha-synucleinopathy and Lewy pathology.
A. Tatariûnas — The intrinsic fluorescence of ceroid-lipofuscin cytosomes accumulating in aging and pathology.
Eus J.W. Van Someren — Circadian disturbances in the elderly.
Johannes D. Veldhuis — Recent neuroendocrine facets of male reproductive aging: an emerging feedback-network perspective.
Bryant Villeponteau — Nutraceutical formulations to slow aging and treat age-related diseases.
Richard Weindruch — Caloric restriction and aging in rhesus monkey.
John Wilmoth — Demography of longevity: Past, present, and future trends.

SIXTH INTERNATIONAL SYMPOSIUM, JULY 21–26, 2002.

Speakers:

In Memoriam: Eduard Schönbaum 1923–2000.
Judith Campisi — Special Lecture: Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes.
C. Bandtlow — Regeneration in the Central Nervous System.
C. Barnes — Hippocampal aging.
M. Gallagher — Effects of Aging on the Hippocampal Formation in a Naturally Occurring Animal Model of Mild Cognitive Impairment.
D. Gems — Body size, insulin/IGF signaling and ageing in the nematode Caenorhabditis elegans.
K. Gordon — Polycyclic phenols, estrogens and neuroprotection: A proposed mitochondrial mechanism.
D. Murphy — The neuroprotective effects of estrogen on the aging brain.
F. Lezoualc'h — Human serotonin 5-HT4 receptor and the amyloid precursor protein [APP] processing.
B. Lockhart — Cognition enhancing or Neuroprotective compounds for the treatment of cognitive disorders: Why? When? Which?
J. Macklis — Molecular Manipulation of Neural Precursors In Situ: Induction of Adult Cortical Neurogenesis.
J. Mattison — Caloric restriction in Rhesus monkeys.
F. Naftolin — Vitamin E delays the onset of hypothalamic reproductive failure in aging female rats.
M. Oettel — Selective aspects of endocrine pharmacology of the aging male.
H. Ooboshi — Brain ischemia as a potential target of gene therapy.
B. Pakkenberg — Aging and the human neocortex.
G. Paolisso — Glucose regulation and oxidative stress in healthy centenarians.
M. Racchi — The pharmacology of amyloid precursor protein.
C. Rauser — Aging, fertility and immortality.
D. Skene — Melatonin rhythmicity: effect of age and Alzheimer's disease.
J. Syka — Auditory system and aging.
R. Verwer — In vitro studies on adult human post mortem brain tissue in relation to aging.
G. Wick — A Darwinian-evolutionary concept of age-related diseases.
A. Wirz-Justice — Dawn-dusk Simulation Light Therapy of Disturbed Circadian Rest-activity Cycles in Demented Elderly.
J. Zimmerman — Nutritional control of aging.

SEVENTH INTERNATIONAL SYMPOSIUM, JULY 18–23, 2004.

Speakers:

C. Dominique Toran-Allerand, New York, New York, USA — Special Lecture: Estrogen and the Brain: Beyond ER-alpha and ER-beta
Alexander Bürkle, Konstanz, Germany — Poly ADP Ribosylation and Aging
Natalia Danilovich, Montreal, Canada — Role of the FSH Receptor in Reproductive Senescence and Biological Aging in Mice
Luis-Miguel Garcia-Segura, Madrid, Spain — Sex Hormones and Brain Aging
Nestor Gonzalez-Cadavid, Torrance, California, USA — Gene Therapy and Erectile Dysfunction
Jan-Ake Gustafsson, Huddinge, Sweden — The Role of the Estrogen Receptor Beta in Neuroprotection
Nobuyoshi Hirose and Toshio Kojima, Tokyo, Japan — Neurotransmitter Function in Centenarians
Eef Hogervorst, Oxford, UK — Testosterone and Alzheimer's Disease
Martin Holzenberger, Paris, France — IGF-1 Signaling and Aging
Xudong Huang, Charlestown, Massachusetts, USA — Novel Alzheimer's Aß Metallobiochemistry and its therapeutic implication
Ilpo Huhtaniemi, London, U.K. — Genetic Polymorphisms and Male Aging
Pidder Jansen-Dürr, Innsbruck, Austria — Oxidative Stress in Endothelial Cell Aging
Kay Lund, Chapel Hill, North Carolina, USA — Transcriptional Mechanisms of Hippocampal Aging and Memory Loss
Michal Karasek, Lodz, Poland — Melatonin, Human Aging, and Age-related Diseases
Mary Ann Ottinger, College Park, Maryland, USA — Reproductive Aging in Birds
Vladimir Patchev, Jena, Germany — Neurotropic Action of Androgens: Principles and Mechanisms
Thomas Perls, Boston, Massachusetts, USA — Exceptional Longevity in the Human
Pat Prinz, Seattle, Washington, USA — Sleep Impairments in Healthy Seniors
Michael Rowan, Dublin, Ireland — Mechanism of the Effects of Amyloid Beta-Protein Oligomers on Synaptic Efficacy
Marc Tatar, Providence, Rhode Island, USA — Endocrine Regulation of Aging in Drosophila
Klaus Turnheim, Vienna, Austria — Drug Therapy in the Elderly
Monique Vallee, Bordeaux, France — Neuroactive Steroids: New Markers of Cognitive Aging

EIGHTH INTERNATIONAL SYMPOSIUM, JULY 23–28, 2006.

Speakers:

Greg M. Cole, USA — Special Lecture: Insulin resistance, TZDs and aging
Bart Braeckman, Belgium — Genetic control of longevity in C. elegans
Alessandro Cellerino, Italy — Aging in a short-lived annual fish
Francesca Cirulli, Italy — p66Shc-/- mouse as a model to study susceptibility to stress and aging
Ana Maria Cuervo, USA — Alpha-synuclein and autophagy
Krishnan M. Dhandapani, USA — TGF-beta and neuroprotection
Christopher Heward, USA — Developing a SNP-based test for Alzheimer's Disease
Ilpo Huhtaniemi, UK — The impact of polymorphisms in genes regulating pituitary-gonadal function on gender-specific aging of European men
Felix Kreier, The Netherlands — Hypothalamus – leptin and hypothalamic function
Anthony LaMantia, USA — Neurogenesis
Frederic Mery, Switzerland — Trade offs in long-term memory formation
Alon Monsonego, Israel — Immunotherapy of Alzheimer's disease
Lisa Mosconi, USA — Early detection of Alzheimer's disease
Gerald Muench, Australia — Advanced glycation products
Antonio Musarò, Italy — Neuroprotective effects of a local isoform of IGF-1
Linda Partridge, UK — Fecundity versus longevity
George Roth, USA — Caloric restriction mimetics: the next phase
Norman Sharpless, USA — Cancer and tumor suppressors
Csaba Söti, Hungary — Protein toxicity and cellular defense mechanisms: the role of chaperones
Robert G. Struble, USA — Estrogens and glial function
Georg Wick, Austria — Atherosclerosis Risk-factors in Female Youngsters (ARFY) Study
Judy Wong, Canada — Role of Chromosome Maintenance in Human Disease and Aging

NINTH INTERNATIONAL SYMPOSIUM, JULY 20–25, 2008.

Speakers:

Elizabeth Blackburn, San Francisco, CA, USA — Special Lecture: Telomeres and telomerase: their implication in human age-related diseases
Dorothee P. Auer, Nottingham, UK — Brain imaging in Alzheimer and Parkinson's diseases
Nir Barzilai, Bronx, NY, USA — Central regulation of peripheral insulin action
Holly Brown-Borg, Grand Forks, ND, USA — Long-living growth hormone receptor knock out mice: Potential mechanisms of altered stress resistance
José M. Carrascosa, Madrid, Spain — Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging
Terry Combs, Chapel Hill, NC, USA — Neuroendocrine Inhibition of Glucose Production and Resistance to Cancer in Dwarf Mice
Alejandro F. De Nicola, Buenos Aires, Argentina — Steroid protection
Ettore Ferrari, Pavia, Italy — Pineal, adrenocortical and thyroid function in autonomous centenarians
Luigi Fontana, St. Louis, MO, USA & Rome, Italy — Neuroendocrine Factors in the Regulation of Inflammation: Excessive Adiposity and Calorie Restriction
Laura Fratiglioni, Stockholm, Sweden — Prevention of common neurodegenerative disorders in the elderly
Lance J. Kriegsfeld, Berkeley, CA, USA — Reproductive aging
Günter Lepperdinger, Innsbruck, Austria — Leptin receptor/CD295 is upregulated on primary human mesenchymal stem cells of advancing biological age and distinctly marks the subpopulation of dying cells
Paweł Liberski, Łódź, Poland — Kuru: its ramifications after fifty years
Valter D. Longo, Los Angeles, CA, USA — Linking Sirtuins, IGF-I signaling, and Starvation
K. Lenhard Rudolph, Ulm, Germany — Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status
Thomas Samaras, San Diego, CA, USA — The Role of Height in Human Longevity
Heidi Scrable, Charlottesville, VA, USA — Running on empty: how p53 controls INS/IGF signaling and affects lifespan
Natalie Sampson, Austrian Academy of Sciences, Austria — Integrated networks of sex steroid hormone metabolism and cytokine signalling in the pathogenesis of age-related prostatic disease
LaDora Thompson, Minneapolis, MN, USA — Mechanisms of sarcopenia during mammalian aging
Aleksandra Trifunovic, Stockholm, Sweden — Somatic mtDNA mutations and ageing – facts and fancies
Rudi Westendorp, Leiden, The Netherlands — The influence of age on the association between cholesterol and cognitive function

TENTH INTERNATIONAL SYMPOSIUM, JULY 25–30, 2010.

Speakers:

Greti Aguilera, Bethesda, MD, USA — HPA axis responsiveness to stress: Implications for ageing and well-being
Craig Atwood, Madison, WI, USA — Testing the Reproductive-Cell Cycle Theory of Aging
Andrzej Bartke, Springfield, IL, USA — Insulin signaling, calorie restriction & aging
Christian Benedict, Uppsala, Sweden — Intranasal Insulin: A future therapy to improve cognition in patients suffering from Alzheimer's disease?
Rochelle Buffenstein, San Antonio, TX, USA — Attenuated aging in the long-living naked mole-rat; endocrine and neurobiological changes
Rafael de Cabo, Bethesda, MD, USA — Calorie Restriction: Is It All About Appetite?
Monica Driscoll, Piscataway, NJ, USA — Healthspan Genetics and Tissue-specific Aspects of Age-Associated Decline: Worm Secrets for Healthy Aging
Ehud Cohen, Jerusalem, Israel — The insulin/IGF1 signaling pathway couples aging and neurodegeneration: from worms to mice
Rita Effros, Los Angeles, CA, USA — Telomere/telomerase dynamics in the immune system: effects of chronic infection and stress
Thomas Flatt, Vienna, Austria — Endocrine Regulation of the Trade-Off between Lifespan and Reproduction in Drosophila
Don Ingram, Baton Rouge, LA, USA — Glycolytic Inhibition as a Strategy for Developing Calorie Restriction Mimetics
Brian Kennedy, Seattle, WA, USA — Longevity pathways and Age-related disease
Gordon Lithgow, Novato, CA, USA — Common mechanisms of neurodegeneration and aging suggested by genes and chemical manipulation of lifespan
Bernd Moosmann, Mainz, Germany — Evolutionary proteomic adaptations towards longevity and stress resistance in animals
Marie-Christine Pardon, Nottingham, UK — Retardation of Alzheimer's-like pathology by mild stressors
Clemens Steegborn, Bochum, Germany — Molecular mechanisms that modulate mitochondrial lifespan regulator proteins
Dick Swaab, Amsterdam, Netherlands — Aging and dementia in hypothalamic systems: functional consequences
Ignacio Torres-Aleman, Madrid, Spain — IGF-1 in the aging brain
Eleni Tzima, UNC, USA — The role of hemodynamic forces in endothelial dysfunction and vascular aging
Alexander Vaiserman, Kiev, Ukraine — Early-life etiology of age-related diseases: epidemiological evidence
Holly Van Remmen, San Antonio, TX, USA — Oxidative stress induced alterations in skeletal muscle and neuromuscular junctions during aging
Barbara Viviani, Milan, Italy — Cytokines and neuronal channels: a molecular basis for age-related decline of neuronal function?